Originally posted by operator616
Vangaard should win.
They already had an encounter in Fantastic Force #12, where Psi-Lord (teenage Franklin) let go of his inhibitions, and unleashed a big bang on him, which Vangaard tanked. While it was hinted that Psi-Lord couldn't have survived it by hiding in some pocket dimension. We know that Vangaard does possess universal level of power, since he goes around destroying timelines/universes across the entire omniverse, so he should have enough power to destroy Franklin.
He's erased over a million universeS and counting.