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Doom in his armor, obviously.

Loki has no weapons.

Just hand-to-hand. Who wins?

Probably doom due to his damage soak.

Who hadms Doom gone against in hand to hand in regular armor?

Originally posted by ShadowFyre
Who hadms Doom gone against in hand to hand in regular armor? Luke cage

Eh. Loki then.

How strong is Loki? He's above the base 40 imo but does he have high feats?

I don't see how Loki could even damage the armor with strictly physical attacks to be honest.

So I would say sooner or later Doom just beats Loki to death.