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Nathan Drake from Uncharted 3.

VS

Lee Everett from Walking Dead: Season 2.

Round 1:Gunfight.
Both combatants gets a Colt M1911A1 loaded with 24 bullets.

Round 2: Fistfight.

The fight takes place inside of a warehouse filled with crates.

Who wins and why?

Drake stomps the shit out of him.

Lee could probably take Rick Grimes, but Nathan Drake would beat the entire WD cast at the same time.