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Pretty simple, a lot of these characters get pretty far on boards because they have an insane healing factor and that's it. The ones here are all still pretty badass though imo. How far in formidability do y'all think these characters would drop if they had no healing factor to rely on? How many times has it won the story for them? A few have further stips.

Deadpool
Wolverine
Lobo
Godzilla(does not evolve,adapt,gain random new powers, or change form)
Hulk (stays baseline strength)
Invincible
Dos Doomsday (does not evolve/adapt, his powerset as of DOS but anything retconned in later is allowed)
Flash(none of that silly shit he does is allowed, he gets his speed and imp punch).

Oh, and here's a fight so it doesent get closed or something. Logan runs this gauntlet with no hf of his former fights.

1. Cyclops (starts at 10m)
2. Hulk (with no hf)
3. Sabertooth
4. Magneto (blind,deaf, paralyzed from the waist down but knows Logan is coming)

Well a lot of them are really squishy, so no regen means they wouldn't get very far.

Logan at least has adamantium covering his vital organs, but Lobo? He isn't even bulletproof. Hulk etc would fall the first time someone brought an adamantium bullet to the battelfield.

Flash would still get quite far, though, IMO. In comics, most of the time that's all he uses.