Deadpool wins.
This isn't even a question.
Deadpool, an insane healing factor, cursed by death not to be ale to die, expert assassin with inhanced reflexes/speed/agility/strength.
Plus, a quick and insane temper with no remorse for beating your ass to death(see typhoid mary)
Versus
Pyro, a man who can control fire and shoot it at you.
Yea. That's true... but I autimatically assume that everyone against an obviously more powerful guy has had recent, secret upgrades and gained hordes offanboys,so... but yea, it's DP.
I'm pretty confident in Deadpool to win this. After all, when it comes down to it, Pyro is just a man. A normal, every day human. By this, I am referring to his speed, agility, fighting ability.
Deadpool could do this without weapons, and with one hand tied behind his back. Quite literally. Deadpool has the speed and agility to dodge fireballs, and even if he had to walk through a wall of fire, he could heal from it, no problem. At which point, Deadpool could procede to snap Pyro's neck with two fingers, as he has exhibited the ability to do.
Pyro steps forward. He clicks on the ignition to set his flame throwers on. His chest hurts and it ain't the Legacy virus. Its three bullets Wade has planted in this guy. Pyro is dead before he hits the floor.
Gender: Unspecified Location: One for the other hand
Well considering that Pyro only control fire and can't create it so the fire is basicly normal fire and would be able to melt any metal projectials shot or thrown at him he would be toast.