It didn't against Shen Kuei. Or that axe guy from Osborn's Thunderbolts.
If Bane crushes Wades head, it won't kill him, but it should drop him long enough for a win.
....Still going with Wade...
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I voted for Deadpool, because he strikes me as more well rounded. Super strength, great agility, respectable combat skills and a top notch healing factor + creativity:
You only have to hurt Bane once.
I mentioned biting his throat out, Enzeru pointed out his creativity.
Not a huge stretch to imagine this tactic by Pool.
A combination of CIS and PIS, his HF couldn't handle a blade being shoved through his chest. Being impaled through the heart didn't stop him from beating the serpent society and taking down Taskmaster. Who humiliated Shen Kuei btw,
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Both of them are extremely skilled, I'd give neither an advantage.
Deadpool would need something of an advantage to offset the massive strength and durability disadvantage. Hell, I'd barely give him a nod in the speed section.
He's all over the place. Some of the recent feats would put him into 40-50 tons at least.
Since it's mainly H2H I'm not sure how big a difference his healing factor would make. Bane has no problem ripping people to pieces. He tore through owls easily enough, and it seems like their durability is more than deadpool's.
I think deadpool's chance is his speed and skills. I can't imagine anyone, even Bane, taking many hits from him....assuming he's serious.