Death (Marvel), she has shown desire and motivation to suggest to me she is a villains or anti hero
Jean Grey (IE dark Phoenix saga)
Enchantress (pretty much nearly destroyed Earth)
Hela
It took me awhile to even think of one heavyweight in Wondy's gallery.
Probably that's another reason she's historically done better in guest titles or Justice League works than her own.
No compelling adversaries.
Outside of Circe, other fill-in the-blank sorceresses or witches, and, in SOME incarnations, Cheetah ...?
Blackstarr probably tops the list of non-magic villains, after, of course, the X-Men's own Dark Phoenix. She was originally a spar of the powerful pre-crisis versions of Supergirl and Superman. Time-permitting, I'll provide some visuals later on ...
I understood it straight away, I don't think his wording was unclear really. I think Thor or Superman as Hela, the Enchantress, Karnilla, Knorda, Loreli, Ursa, Faora, Silver Banshee, Blaze, Amazing Grace, Zaora etc. They both have loads of tough female villains who would give Wonderwoman a run for her money.
Hulk, with Betty yapping in his ear constantly. Women, amirite? *cracks open a cold beer*
On a more serious note, the question was succinctly and clearly put.
JLA with Gamanemnae and the Queen of Fables. Thor with the aforementioned Jela and Enchantress/Loki. Hercules has Hera and assorted Greek goddesses/monsters. Charles Xavier has Cassandra Nova.
And Batman has Poison Ivy. Who recently took control of the entire Earth....
One thing I've notice with a lot of female villains for male heroes, is that they become a love interest for the hero. Sometimes they start out that way like Star Sapphire/Hal or it happen laters Fatality/John, and they end up becoming anti-heroes or heroes for a while like Killer Frost/Firestorm.