Shaggy Man ain't THAT good. Yeah he heals almost instantaneously, and can take on the JLA by himself. But Thanos could probably just vaporize a city-sized area around Shaggy Man (including SM himself) before he could heal...he's on another level.
Yeah, he's at or slightly above Doomsday and Supes in strength and durability...but that doesn't put him on Thanos' level. Shaggy Man can take blows from Superman. Thanos can take blows from Odin. He's on a completely different level.
Thanos can probably put him down. Even if his durability is around Doomsday's level, repeated pounding will eventually take its toll. Thanos is powerful... Surfer can drop planet busting bombs, Thanos can channel a LOT more power cosmic than Surfer can.
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Hmmm...let me rephrase. Thanos can trade blows with Odin. He can dish it out pain as well as take it. Shaggy's almost as durable as it comes, but he's in over his head. Maybe he survives. Maybe. But he definitely doesn't win, and Thanos might just kill him.
Shaggy's kinda like Juggernaut. Invulnerable as all hell, but there's gotta be a limit. Put, say, Galactus up against Juggs and Big G would output more energy than Juggs can handle, even with his god-powered durability. And since Shaggy is more about instant healing than actual invulnerability, an energy source strong enough to instantly destroy him (since even the JLA can harm him) wouldn't give him any time to heal. That's what Thanos could do. Like I said...maybe it's not enough and it's just a stalemate...but if it is then Shaggy's lucky.
Actually, it's the General, not SM.
Anyway, Thanos takes this with ease.
He's on a strenght level far above that of SM, and come on, wanna talk about durability to Thanos?This guy took blasts from Tyrant, he can probably overload General's heal factor and then teleport him into the sun, killing him.
But what does he do against Etrigan? Although he never uses, he is one of the most practitioners of magic in the universe... He's more powerful than Merlin and Morgan Le Fay in that department... making his magic nearly limitless... and he's pretty impervious to damage... has Hellfire at his disposal... you guys are counting him out way too quickly. He's a huge factor in this fight.