Spidey Villians.
Green/Hob/Demo- goblins
Doc Ock
Rhino
Sand Man
Electro (original human version/energy versions)
The Vulture
Sandman
Venom/Carnage
Vs
THE BIG MEG!
A City with way better tech then places like "Gotham City" but its "police force" is manned by normal humans only with WAY Bette Tech and no reluctance against unleashing it against the criminals.
With Dredd involved the villains would be off to resyk pretty quickly. This is the guy who took down the 4 Dark Judges, Sabbat the Necromancer and about a billion zombies, countless monsters and extraterrestrials, killer tyrannosaurs, armies of robots, vampires, the list is endless. Throw in the rest of the Justice Department and their psychics, and all the lethal hardware at their disposal, the villains are toast.
He's always had it, so did Venom. The story DS referring to happened quite recently. Carnage took over a small city turning everyone into mindless symbiote zombies. Avengers tried to stop him but he also took over Thing, Cap and Wolverine. He's a tough MF.
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Azula: My mommy didn't love me so I'm going to burn down your village.