Poll
40%
60%
I'd go with Colossus in this one. First of all I'm not sure Spiderman's webs would be strong enough to stop a guy who is in the 100 ton range (unless someone has a scan of it doing so). Secondly all Colossus needs to win is a single punch while Spiderman really can't harm him. Lastly, while Spiderman has the speed advantage and spidersense, Colossus has far greater stamina. He can fight at peak capacity for several days before he tires. Eventually, Spiderman will tire and get hit by Colossus, and when that happens the fight is over.
Well Colossus will be hard pressed to land a shot on Spidey. But if Spidey spent most of him time evading attacks from Colossus he would have a hard time moutning some offense himself. But the webbing tactic may work temporarily.
So I say Spidey gets tired and gets sloppy with his agility and Colossus ends up hitting him with Charlies limo or a rock or something.