Priscilla's a strong individual. No where near Whitebeard's strength but neither were Blackbeard and friends. Granted that Whitebeard did go through a whole battle with Akainu before then, he was still stabbed and shot: just saying.
Looking back at Whitebeard one-shotting that giant with a fist-quake, I admit Whitebeard can get that headshot in. As sated before, Priscilla herself isn't very destructive however she can effortlessly kill people in her series that are. She's at least at mid-Sonu levels; not impressive as either Kizaru or Mihawk but fast enough right?
I wonder how Logia users would fair off against the Destroyer statue: not the shell but the real thing. I'd assume they'd win but how exactly would be hard to guess.
Depend on how Whitebeard attacks Priscilla. Assuming that he slices her in half vertically, then she's pretty much dead. If it horozontally, she could regenerate from it however it won't be instant. So Whitebeard can make omni-directional quakes right?
She's fast enough to fly out the way. She can catch arrows moving at hypersonic speed(or is it) so I'm assuming she won't get hit the instant the fight starts.
Claymore characters have pretty good durability feats and their regen appears to compete with OP strength as far as mid-tier people are concerned. I'm not arguing Whitebeard losing by any means, I am arguing that Priscilla is going to put up a fight before losing and not get stomped.
I think I'll go with this. The odds are too high of a head shot happening, but she's still really fast, really dangerous, definitely strong enough to inflict good damage, and able to recover from anything short of a headshot no matter how powerful.