I guess it's possible, but I think that historical percentages of him doing that should outweigh one time events likes the one that you're presenting here. But it is possible.
Under conventional means, Cain was reduced to a skeleton by Despayre? I think that's how you spell it but not entirely sure. I'm pretty sure that any character can die, but I'm not seeing how a physical character like Doomsday would be able to do something that not even magic was capable of doing to him. So let's do away with it being impossible for Cain to die, and go with you would likely need a particular item or specific spell to kill him. Doomsday in this case is in possession of neither. On the other hand, Doomsday wouldn't die either, so to be honest with anyone interested, I have no idea who would ultimately win this.
Doomsday is stronger than Cain, but less durable. Cain isn't strong enough on average to put Doomsday down for the count, which is why I believe that this would be an eternal stalemate.
My reasons for this is because Cytorrak has both decreased, and increased Cain's level of power on panel. So while DD evolves, there would be nothing to hinder Cytorrak from giving Cain more and more power to keep up with these changes. whoever wins this won't be doing so for a long time IMO.
my intention was to show that juggernaut can be hurt physically and maybe even killed. if its by a sword or the way onslaught did it. facts are he was hurt physically or was portrayed as able to get hurt. it only means it takes a lot of power. on the levels of celestial tech or onslaught is a high level. but it can be avhieved in my book. so i stand by my initial statement that with enough force he can be overpowered and hurt and i believe doomsday can reach those levels.