Thanos takes this. The fact that Despero hasn't been beaten by anything other than magic or a plot device isn't proof in and of itself that those are his only vulnerabilities. In order to classify him as only vulnerable to those things, it would have to be firmly established as being the case by DC. To my knowledge that hasn't happened. So to assume such a thing without proper grounds is nothing but speculation.
After Thanos's last upgrade, he took down the Maker and gave Galactus one Hell of a wakeup call. Despero's never displayed that level of power to my knowledge(with out the Flame of Py'tar, or what ever the Hell it's called anyway).
What has Despero shown that would make him stronger then Thanos?
Thanos has been able to go up against guys Odin,Thor with Power Gem ,Champion with Power Gem,Tyrant,hell he even beat the Maker and made Galactus fly for about a mile.
He has the superior fighting skills and powers in this match so one thing is for sure he won't loose at least he will just stalemate Despero.(Despero fights like a retard by this I mean Hulk or Juggernaut.)Thanos also has matter manipulation skills so he could just turn him into stone or screw up his molecules or absorb his life energy.Thanos can also increase his strength by cosmic power.
Despero has never shown to able to put down a Thanos level character his best showing was in Virtue and Vice where he beat 4 Superman level characters at a time.Which is pretty impressive but Thanos has at least as good or even better showings.
As for the Despero will possibly try h2h first cause he always does that Thanos gives him a spanking just like he did to the Champion
after Despero will realise that he can't handle Thanos in h2h fight so he will start blasting around which will be encountered by Thanos's shields.
What does the IG have to do with this? He never fought anyone without the IG, and he kicked everyones ass with it.
He WAS a clone when Thor beat him.
Drax is basically Thanos's weakness, and he NEVER beat him in a strait up fight(he just sucker punched him from behind when Thanos was other wise occupied). Using that as an example is about the same as saying that Supes can be taken down by a single bullet, since he was and Batman had to save him(even though the bullet was made of K-Nite).
The ONLY time Surfer beat him was in an astral battle, when both of them voluntarily had their powers taken away from them.
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Let's make this Simple, Thanos can easily beat Top tiers. SO can Despero. Thanos cannot be dispatched and it has consistantly been shown that only a mad Galactus or Odin or Tyrant could ever crush him. Despero has only been shown to be out right physically beaten by an Earth ANgel who was superior to even the New God's in thier giant forms. Despero has also never been dispatched by any means other than The highest caliber of Magic users or Supernatural force. To me it seems like a dead even fight. I give thanos More dmg output as his Cosmic Blast can do far mor dmg than Despero's TK. But Despero's Tk isn't weak by any means and His better TP abilities ensure it won't be a cake walk for Thanos. IT is likely a stalemate since Despero Oozes will power and wont' be turned into stone or anything silly like that.
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When he's faced beings like Zatanna who couldn't have turned him to stone and didn't. I dont' remember if he's faced a GL, but they certainly have matter transmutation power and none of them have either. And exactly how many people have Thanos fought that he's turned into something to end the battle?
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OR that Despero couldn't just take over Thanos's body. Taking over someone's body is far beyond any telepathic means. It's a spiritual thing. One that I"m sure thanos has no vaunted defense against.
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So is Despero. So tell me, what defense does thanos have to being taken over in spirit? To my knowlege Thanos has no Supernatural defense to a take over of this kind. Doesn't this guarantee Despero the victory?