I don't know isn't Talisman still not very expreinced with her powers I'm sure that a Strange level magic user with but loads of exprience could take her.
Depends, in the past she gained the experience of the Talisman before the current over 10,000 years ago and the Talisman she dons feeds her information as the Gods tell her how to fight and what to do.
That's because she was recovering from brain damage. She absorbed Shaman's Void in seconds to shift through it to find a spell to cure the Remnant Men. Meaning she absorbed an entire universe into her mind and organized it to find what she wants.
Like I said depends, on what era you pick Talisman at.