She's the creative director for the game (she put so much input into the game that she felt it's really her "child") and came down from Tokyo to reveal this game personally at E3. She's also a horror veteran who's been working with Shinji since RE2 (Shinji's successor he's been grooming for years) which just makes this suck all around. There's also the fact that she's leaving just a few months after the games CGI trailer debut at E3 (Cyberpunk is probably nearing the end of its development cycle) which tells me there's development complications. The fact that she's also asking for job offers tells me her departure was situational. You don't leave a position like that without a job lined up.
Your speculating and means nothing until we see an actual game.
This wouldn't be news and nobody would care but she went viral at E3...and now I guess she is the next best thing for gaming.
I assume Shinji Mikami is working on the game and I assume he has complete control of the direction of it. Was she even that important? She was unknown until she was on stage.
And you right, it is a small red flag and the game could be shit. However....maybe she was over-extended her importance.