Driving from L.A. to Florida to deliver a vintage Mercedes and attend his sister's wedding, Sean decides to pick up hitchhiker Nick. From that moment on, his cross country road trip is transformed into a surreal and blood-soaked nightmare. Sean soon realizes that Nick is not the laid back, aimless traveler he seems. He is a vampire hunter who preys upon the Bloodletters, a roving band of forsaken youths who viciously feed on the hapless victims they find in the dead of night, along deserted highways.