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choose any 4 heroes from marvel including at least one of the orginal big 4 (dr. strange, hulk, silver surfer, and the sub-mariner)

here's mine:
1. Dr. Strange
2. Professor X
3. Silver Surfer
4. Gladiator

i chose these because strange's abilities are based on mystical powers. x's is on telepathic powers. surfer's is on cosmic. and gladiator is purely physical.
so you have magic, cosmic power, mind control, and someone who can just beat the crap out of anything. they can destroy one's mind, body, spirit, and material make up all at once. mess with these guys and you're royally FED

Except, I find Proff. X a bit superfluous, given that Strange has better telepathic skillz that killz.

Mine:
1. Strange, ya just gotta have him.
2. Blazing Skull, fits with the Defenders mystic M.O.
3. Llyron, with the Defenders being his superpowered parole officers.
4. Firelord
5. The Air-Walker construct
6. Machine Man
7. Starlight

good point

My new team is as fallows:

1. Dr. Strange
2. Silver Surfer
3. Gladiator
and
4. Enchantress

now not only are your body, mind, matter, and spirit in trouble, but your heart is gonna be broken as well.
tomcat giljotiini pile velho

Here's my Defender team:

1. The Sentry

2. Silver Surfer

3. Dr. Strange

4. Sersi(marvel)

5. Black Bolt

5. Ghost Rider

6. Thor Girl

7. Captain Marvel aka Genis Vell

The magnificent seven.

Ok here goes:
Dr Strange
Sentry
Loki
MoonDragon

Silver Surfer
Quasar
Adam Warlock
Beta Ray Bill
I think this team has all bases covered

1.Adam Warlock
2.Sentry
3.Hulk
4.Black Bolt