Spidey's being stronger doesn't really matter because read this
HE NEVER GOES ALL OUT
Blade always goes all out and always goes for the kill. That right there is why Spidey couldn't possibly beat Blade (outside of the fact that he's more skilled, has equal durability, is faster, and is a lot more experienced) he's taken hella beatings at the hands of Dracula and the Reaper and still got up and still finished the job. It's possible for Spidey to knock Blade out, but that's only if he can get in close enough without being turned into sushi and actually cuts loose (something he didn't even do with his aunt's life on the line).
Has Spidey ever side stepped bullets (a feat a much weaker Frost was able to do with relative ease)? Hell he seemed like he was having a tough time reacting to the Goblins projectiles in the first movie.....
Hmmm, I keep neglecting the fact that this is Movie Spiderman. I dunno about that, then. I still think a movie spiderman could take him, just not as easily.
How? Blade dwarfs Spidey in everything BUT power, in which Blade has fought a comparable much more expierenced and much more rutheless opponent (Drac) and still not only survived the onslaught but came out with the W, not to mention Spidey would most likely only being fighting Blade with the same level of force (maybe a little more) and Blade has MUCH better weaponry to more then dwarf Spidey in destructive force.