It'd definently be awsome if they could make a good story of Blade and Punisher meeting and teaming up, however I don't think they'd do it since their story lines don't really go togather. I may be possible to have Wolverine and Punisher meet after the Punisher movie and the spin off Wolverine movie, though it still would be hard to merge their story lines.
Hey guys, this movie could be so cool if they made it the dark, disturbing tale that it is into one psyco's brain.... oo just think...
however I have no confidence in this happening, i think it could be a wolverine type escapade, all balls and action! ruining it, the punisher could just have a knife and still be all out action, the question is will they go over the top, making the punisher into a camp punisher like some of the batman's!?