Spider-man vs. Gambit
Someone strike a match. There's a lot of gambit fans on this site.
I don't think there is anyone more suited to agile fighting than Spider-man.
Gambit has his kenitic energy that actually made Gladiator lose his breath, so hes tough as all get out.
I think it would be a chase cause Gambit likes to even the odds by drawing an opponent after him, but this opponent would catch him and pounce on him.
Gambit would wind up hanging from a lampost, his kenitic eyes outshineing the light above his head.