Original gem guardians vs anyone

Hypothetically, could, say Darkseid, Lex Luthor or even Dr Doom (individually) have obtained the complete set of Infinity gems from their original guardians? Are they smart or cunning enough?

Time - Gardener
Space - Runner
Reality - Collector
Power - Champion
Soul - In Betweener
Mind - Grandmaster

Well i think it would be a bit hard for Darkseid or Lex Luther coz there in different universes. And i doubt Dr.Doom could have.

Doom or Darkseid could. The Guardians aren't exactly genius.

Krissy Von Doom was a sock 🤨

Soul and power are pretty hard to get a hold of.

i feel dr doom could have done it. darkseid would have tried but i dont see him pulling it off.

Darkseid could actually beat a handful of them, so he should be able to get a couple. If he went for the in-betweener and runner last he could make it.