Dr. Strange vs. Thanos
How well would magic fair against Thanos. Will Dr. Strange's spells hold him.
I don't know all that much about Strange. Some guest appearences and a few comics is all. I've seen him on a couple adventures. He's usually up against some tough as nails opponents with really bad armies between Strange and the opponent.
Doctor Strange should win, he's too versatile. He can use so much spells (crimson bands of Cytorrak, the so-called clamp of containment, he can teleport, is telepathic much stronger than one would think and can even - I think - manipulate time).
He can possess someone, is even much stronger in his astral form, can turn himself invisible, can create illusions and so on. He also has this extremely powerful psychological attack that even knocked back Galactus once - can't remember the name however.
He is the sorcerer supreme for a reason. And last but not least, he's used fighting powerhouses AND he's a very cunning character.
Dr. Strange has a very good chance of beating Thanos. With the Ruby of Dominion, he could easily overcome Thanos's small-scale telepathy, and make Thanos do his bidding. With the Cloak of Levitation, Dr. Strange can achieve warp flight speeds. He also has the Book of the Vishanti. He knows just about every spell there is.