The comic one would destroy the animated one badly.
If it is the comic book version, than Slade doesn't stand a chance, simply because he's got nothing on Superman. Maybe it's true that the new animated Slade can't die (which I think he probably can, but the Titans just aren't powerful enough) than Slade MIGHT stand a chance from the immortal standpoint. But I doubt anything he could do would phase Supes...unless he got some kryptonite...but that's a whole other thread.