How long can Superman live?
IIRC, in one chapter of "Lois and Clark", he said to Lois "no one knows how much he has", which means that not even Superman lives forever.
Biochemical changes (as free radicals) in cells over time may play an important role in senescence, but the essence of those changes remains to be determined. Aging is just an accumulation of complex side effects piled on top of each other in a somewhat random uncontrolled way.
The cellular structure of a Kryptonian is similar to that of all humanoids. However, a certain chemical makeup in the ribosomes is capable of absorbing solar energy and storing it. Once the ribosomes achieve saturation levels of this radiation, they begin to re-radiate the energy in the form of a bioelectric forcefield.
Because Kryopton's gravitational field is 50-100 stronger than Earth's, the kryptonian cells are much stronger and denser than a human's. In addition, the bioelectric field which surrounds the cells, makes them thousands of times tougher. The Kryptonian mitochondria absorb certain wavelengths of the electromagnetic radiation emitted by solar fusion. Even under a red sun, this yields increased abilities, which are multiplied a thousand-fold by a yellow sun. The solar energy supplements respiration, such that when cellular materials (perhaps Kryptonian ATP) combine with glucose, they produce abilities beyond those of humans under a yellow sun.
Due to the highly charged nature of his solar storage systems, his immune system deals with most normal poisons and diseases quickly and with no ill effect. Radiation and similar harmful energies are similarly neutralized.
The result is thousands of times longer a life-span for Superman.