MM has really no chance of survival because SM has a foe he faces on a regular who is similar and that is Mysterio. As a matter of fact I would rather MM to be in a fight against me than Mysterio because with Mysterio you are dealing with an entire environmental change. Mysterio can alter the surroundings to any VR world of his choosing.
MM is at a disadvantage because when Parker closes his eyes and really focuses on his spider senses,it is able to guide him precisely to whatever it is he is looking for. It acts as a precise radar,which he learned to harnass through Madame Web's teaching. So SM can just block out his senses and focus among the duplicates and find the real MM and knock him out!!!