damn, i love spidey, but this is a tough one . . .
could he avoid them? yes. the problem would be knocking them out or confining them. it would be . . . difficult to get them in positions where they couldn't cut free. the only logical way i can see MIGHT go like this:
he seperates them and takes them one at a time. how? he could latch onto any one of their backs in the battle (let's say LD) and quickly toss them a mile away. now it's down to 2 on 1. we've seen what his webs can do to sabes's face (as much as so many sabe fans hate that reference, it DOES stand to reason - imagine someone pouring liquid steel on YOUR face and trying to scratch it off!) so if he got rid of LD then webbed sabe's face that would leave him with just wolvie for a while. being as i'm one that thinks spidey can take him - especially with some judicious web placement - he could take wolvie out, finish sabe's even if its just gobs of webbing while he's blinded, then wait for LD and beat her the same way he beat sabe.
and if he was malicious, he could dump their webbed bodies in a river. ain't no healing factor bringing 'em back from that.
probably wouldn't happen that way, but, based on what we know of the characters, it could . . .