Next time can you give us some more choices? Four is very low when talking about all of Spider-man's bad guys.
WAF
WAF3001Randomnosity
It's all about Just a Guy Named Joe!
SCA
Scarecrow756The Joker
Without a shadow of a dought my favourite Spider-man villains are Doc-Ock, Venom and Green Goblin.
DIG
DigiMark007Forum Leader
The Looter!
Crappy-ass villian from Amazing #3? (somewhere in the 30's). Respect the crappiness...more time for Petey to mack on Gwen and M.J. And, let's be honest, that's more important than saving the world any day.