This won't be a curbstop but Spider-Man wins. He knows about her phermones so even if his new costume doesn't block them at least he'll expect them. He's stronger, faster, more agile, has his webs plus his spider-sense to help him dodge her venom blasts. She can fly and thats an advantage, plus she's a better fighter is is fast enough to land some hits and strong enough to make them hurt. He does have more experience than her and that will be a plus. Good match up but Spider-Man ftw