Difficult. I am incline to say yes BUT Thanos is never really taken off guard. At best just amused. So a surprise attack might just make him smile and find the whole thing an amusing distraction.
Also he has an armada of futuristic state of the art spaceships at his disposal, one in particular I forgot it's name but he used it in Infinity Wars saga. That thing alone conquered numerous star systems and galaxies
Originally posted by manjaro
lets see who repels galctus on a regular basis and who admits that galactus his among the beings he either fears or doesnt wanna have anyhting to do with? hmmmm? *scatches chin*
Yeah but most of the time it's not the FF doing something directly to G.
It's either Watcher warns them, Reed gets some kind of clue through his many inventions scanning the cosmos or Sue get's a premonition.
C'mon dude, be fair FF have never woke up one morning and said" WOW here comes Big G.LEet's go up there and kick his ass".
Oh and of course Silver Surfer mixing up in there somehow.
Let's see Reed seeking help from Stark Enterprises or Wakandan government. Or maybe taking a trip to the negative zone to find the ultimate nullifier or some other relic. C'mon don't boost FF on the back of Thanos. He has proven his worth time and time again.
Thanos is what Doom aspires to become.
Nova
http://home.mchsi.com/~nova64/novadossier.htm
Captain Marvel II
http://www.marveldirectory.com/individuals/c/captainmarvelii.htm
Wonder Man's fast and strong. He can lift over a 100 tons if focused and angered and can reach speeds of Mach 33 with ease.
http://www.fortunecity.com/athena/power/955/WBIO1g.htm
Jennifer Kale
http://www.marvunapp.com/Appendix/kalejennifer.htm
Other members could stall Thanos, while Kale whips up a banishment spell, or pulls something out her magic book. A cheap win, but it's something they could do.
Heroes also have a week of prep, something Thanos doesn't.
They have a chance.
Kale is nearly as powerful as Strange. With her book, she could find something that'll stop Thanos. This book: