Any Culture GSV
http://en.wikipedia.org/wiki/Mind_(The_Culture)
Don't know if this would count as a "scifi vehicle," but my vote goes for the Silver Surfer's board. It's simple (less to go wrong or knock outta commission), effective (relativistic speeds to warp speeds), extremely maneuverable (by virtue of its size, if nothing else), and easy to control (by thought, no mechanisms to manipulate). Which brings me to an aside question: if the Surfer is so darn powerful, how come he needs a board to fly? (one of the great unresolved questions of comicdom, like, How come the Hulk never loses his pants)