No Gems for all of them, or does Adam keep his? What about post Gem powers for Pip and Moondragon (teleportation and TK)? What, no Thanos? Original or remade bodies for Pip and Gamora (big strength and toughness diference)?
With none of the above, I'll lay odds on the Defenders. It's not a done deal, but the Defenders have a huge raw power advantage. Or course there's still Gamora's dagger... you never know.