All depends on which version you want to go with...
http://www.mutanthigh.com/wendigo.html
Yea it all depends if the Wendigo is well written or not. If he well written then he takes this easily cuz he has actually held his own for some time against Hulk and Genis at the same time when well written but when poorly written he and Wolverine together got beat by the Hulk easily, so if he's well written he wins if not he loses.