the only thing that'll save slade is the fact that he'll heal from anything...but on the real he would get massacred by the knives dude.....even Vash the freaking stampede could hardly contain him...plus remember that him and vash have virtual immortality, and eternal youth(meaning he'll live forever unless killed....like wonder woman) cuz remember when they crash landed he left vash in the wreckage for 80 years without food and water, and he survived .
sorry to say that slades reflexes arent fast enuff to pull any stunts that knives wont see coming, and knives doesnt have slight precog, he's full on psychic, with massive telekinetic abilites. so slade would be going up agianst a god
where in all of trigun does it say he is psychic? i must have missed that part. its sounds like u are speculating to me. and slade's reflexes are more than fast enough. his speed is enough to let him keep up w/ flash for the first few steps, and his precog is ridiculous, he took out most of the jla by himself. knives was a bad ass for sure, but slade is badder and a bigger ass.
dude i guess you missed the part where he was taunting vash telepathically, and vash thought he was hearing voices, also that other guy who made all those guys in the bar kill each other(a guy who got his powers from Knives BTW) did the same telepathic taunting, then after the preacher dude was killed, the guy who killed him, Knives turned around and killed him by breaking him apart telekinetcally. so yeah i guess you must have missed it.. plus Knives is a stone cold freaking killer he'll whip out that angel arm faster than you can say kem! and reduce slade and the entire battle field to ash, and there would be nothing he could do to stop it