Hmm, that is tough. Gladiator took out the FF pretty damn easily, but obviously they've grown alot since then so it'd be harder.
I see Sue and WW being the main challenge. Reed knows about Glads confidence weakness so he'd be working on a way to exploit it while the others keep Glads busy. So they'd take it more times than not.
If Glads is bloodlusting he could speedblitz. Only challenge then would be WW. And he'd take her eventually.