Dante VS Ryu Hayabusa
Dante the professional demon slayer VS Ryu the professional super ninja...
I really couldn't come to a solid conclusion on who the winner would be. Both routinely kill demons and giant boss monsters. Dante might have a slight advantage being half demon, but Ryu has a larger arsenal of weapons and probably more training.
Now these are current editions. Ryu from Ninja Gaiden, and grown up Dante (not that wise cracking punk from DMC3)
Dante still has his "demon trigger" and we'll give Ryu his Ninpo....They both have projectile attacks, even though I think bullets are better then shurikens and arrows.
And GO!!!