James Bond is heavily referenced in the series as well, as Brock is essentially a pumped up Bond and actually carries a license to kill. Brock remarked in an episode that killing guys in a tux makes him "feel like James Bond." Colonel Horace Gentleman, one of the members of Dr. Jonas Venture's original Team Venture, speaks with a Scottish accent that sounds just like Sean Connery, one of the many James Bonds in cinema, but actually a knowing jab at Connery's character in The League Of Extraordinary Gentlemen. Additionally, in the episode "The Incredible Mr. Brisby", when Brock is rendered unconscious by a cigarette, he mutters "chloral hydrate..." just as Timothy Dalton did in The Living Daylights.
Other pop-culture references are abundant. Other references, most of which are used as "one-shot" jokes, include Superman, Total Recall, Easy Rider, Mad Max Beyond Thunderdome, The Rocky Horror Picture Show, Apocalypse Now, Clarissa Explains It All, Jim Foetus aka J.G. Thirlwell, Lydia Lunch, Stiv Bators, Henry Kissinger, John Woo films, film director Kevin Smith, the questionable sexuality of members of Depeche Mode, a polar bear from Lost, Voltron, INXS, the Illustrated Wildlife Treasury, Magic: The Gathering, Dungeons and Dragons, Incredible Hulk foam fist merchandise, Lord of the Rings replica sword; representations of characters from Indiana Jones, Magnum P.I., and Knight Rider; the music video for Duran Duran's "Hungry Like the Wolf", and prominently, the late German New Wave performer Klaus Nomi, and punk rock singer Iggy Pop (resulting in a sly joke about "stooges"😉. In the first episode of the first season, the doctor in Tijuana who steals Dr. Venture's kidneys is named Ernesto Guevara, the real name of Che Guevara, who obtained his medical degree in his native Argentina before meeting Fidel Castro in Mexico City in the 1950s.