Aspirin, ibuprofen (Motrin, other brands), and other nonsteroidal anti-inflammatory drugs (NSAIDs) may help with the headache and the overall achy feelings. NSAIDs, though, may irritate a stomach already irritated by alcohol. Don't take acetaminophen (Tylenol). If alcohol is lingering in your system, it may accentuate acetaminophen's toxic effects on the liver.
Experiments have shown that clear liquors, such as vodka and gin, tend to cause hangovers less frequently than dark ones, such as whiskey, red wine, and tequila. The main form of alcohol in alcoholic beverages is ethanol, but the darker liquors contain chemically related compounds (congeners), including methanol. The same enzymes process ethanol and methanol, but methanol metabolites are especially toxic, so they may cause a worse hangover.
Drink fluids. Alcohol promotes urination because it inhibits the release of vasopressin, a hormone that decreases the volume of urine made by the kidneys. If your hangover includes diarrhea, sweating, or vomiting, you may be even more dehydrated. Although nausea can make it difficult to get anything down, even just a few sips of water might help your hangover.
Drinking to ease the symptoms of a hangover is sometimes called taking the hair of the dog, or hair of the dog that bit you. The notion is that hangovers are a form of alcohol withdrawal, so a drink or two will ease the withdrawal. Both alcohol and certain sedatives, such as benzodiazepines like diazepam (Valium), interact with GABA receptors on brain cells. It’s well documented that some people have withdrawal symptoms from short-acting sedatives as they wear off. The brain reacts similarly as blood alcohol levels begin to drop.