Hans Christian Andersen's "The Bishop of Børglum Cloister and his Kinsmen." The titular bishop doesn't seem to care about religion per se; he treats his position solely as a means of getting more wealth and power. Over the course of the story, he repeatedly has his henchmen commit murder and Salvage Piracy, and gets a widowed noblewoman wrongfully excommunicated just so he can seize her husband's estate
Reverend Lovejoy on The Simpsons is kind of a douche. His sermons vary from, at best, dreary recitations of more opaque parts of the Old Testament, to the occasional "fire and brimstone" scaremongering about Hell — and very little of the love and joy that his surname suggests. Some of the really bad stuff he's done is burning books that oppose Christian ideas (not out of fundamentalism; it just makes him more important if his teachings are the only one available), blatantly ignoring what The Bible says (interpreting what's "sinful" his own way), and trying to burn his own church down as an insurance scam. Worst of all, he's horribly intolerant of any other religions (except Jews, he was on really good terms with Krusty's father).
Stephen King's The Dark Tower series features a rare female example: Sylvia Pittston, a large woman who establishes a Christian-like cult to the Crimson King in the town of Tull. She is even pregnant with the Crimson King's child via the Man in Black, though Roland destroys this hellspawn by forcing his gun up her…uh, skirt, which drives her mad. Sylvia's influence over the town is so great that she's able to successfully convince the whole populace to attempt to kill Roland. No one, including her, survives.
Buffy the Vampire Slayer’s Caleb (played by the awesome Nathan Fillion) is a psychotic misogynist and serial killer who used his sermons to lure impressionable young women to him and then brutally murder them. This was before he became The Dragon for the Big Bad in the universe, who granted him super-strength and an army, then tasked him with massacring the Slayer Potentials and the Watchers. He took to his mission with sadistic glee, reciting twisted prayers and Biblical references as he casually broke arms, snapped necks, and put out eyes. Caleb was, bar none, the single vilest villain in Buffy canon, even surpassing Angelus in depravity and pure hatred.