Superhero best-friends

Sasquatch is probally James Hudson's best-friend. As said in Wolverine vol.2 James and Wolverine's relationship is James is like a foster father to Wolverine or said to be a brother in Uncanny.

Wolverine and Puck are still close, but they were never best friends. Just really good ones.

Iron Man & Captain America aren't as buddy buddy as a lot of you seem to think

Cap quite often has problems with the way Tony does things.... in fact Thor is way more pally with Iron Man than Cap is

wolfsbane and moonstar are often labaled as soulmates