It would be a hard fight that would destroy many things around them. The hero's would stand a chance. It also depends on who's animating it. Someone like wolverine or iron fist knows a lot of martial arts could beat the hero's. Give it to batman with prep time (LOL) who knows what he could do. But if it was some punk the hero's could definatelly win.
yeah but if you put some normal joe i it then it would get beat down. And skyfather beings don't move mach 22 while running like superman does. That's only when they are flying(for the ones that can fly) mach 22 is 7486.3 miles per flipping second how could the person in the destroyer even see that coming?