what size is the arena? can spidey cling to it out of reach? if they can all reach him, they could win. if it turned into a melee they probably would. spidey's fast, but he ain't dodging all those guys at close quarters. if he can get of of range where he could use his webs effectively, and have some open space to fight in, he COULD pull it off, but it would be very tough and he'd need to go bloodlust/no-holds-barred.