Spidey should be the easiest for the FF to beat. Both Ben and Reed can both have around class 85 strength so one shot from them would kill Spidey. Sue has the force fields (not much Spidey can do against thoes) and he can't even get near Johnny unless Johnny lets him.
Wolverine doesn't stand much of a chance either. Either Ben or Reed could go h2h against him and stand a good chance of winning. Add Sue and Johnny to the mix and Wolverine is in trouble.