Slade and Mister X vs. Spiderman

I know about Slade but looked up Mister X and he seems to be damn good as well. How would their supreme hand to hand skills fare against everyone's friendly neighborhood, well you know...

Slade would be a handful on his own. What can Mister X do?

Slade can solo Spidey himself in at least 5 of 10, add help from pretty much anyone and it becomes a fairly landslided victory.