Cap has already manhandled mr. Hyde. Anyway, Spider-man should win this but not because of ABC logic, but because he is a lot faster and the strength difference is not that significant (as in ranging from 70 tons above). He is warned for every attack Hyde would pursue due to SS and similarly counter them. Spider-man has every bit of an advantage towards him with the exception of strength and probably Hyde's durability which is pretty inconsistent.
Originally posted by Scoobless
Spidey beat Hyde with a broken ankle back during his "Identity Crisis" many years ago.... they fought in a lift (an "elevator" to you damn foreigners)
He also fought him with a sprained ankle in a penthouse years ago aswell, hyde had him beat in strength and durabilty but after spider-man webbed his face and threw him through 5 or 6 walls and off the top floor of a skyscraper Hyde wasnt getting up...(well ok he did but he fell down again straight after)