Ask the Dust
Val Kilmer and Johnny Depp were attached to the film at various times.
Actor who got the part: Colin Farrell
The Brothers Grimm
Depp was the first choice to play Will Grimm.
Actor who got the part: Matt Damon
Confessions of a Dangerous Mind
Mentioned as a possible star of director George Clooney's movie about Chuck Barris.
Actor who got the part: Sam Rockwell
Ferris Bueller's Day Off
During his interview on "Inside the Actors Studio" Johnny Depp said that he was offered the part of Ferris Bueller but was unavailable for it. He also said that Matthew did a great job with the role.
Actor who got the part: Matthew Broderick
Hulk
Considered to play Bruce Banner.
Indecent Proposal
Depp was considered for the lead role of David (Woody)
Actor who got the part: Woody Harrelson
Interview with the Vampire
Johnny Depp turned down the lead role of Lestat.
Actor who got the part: Tom Cruise
(Johnny woulda kicked ass in that movie..)
Legends of the Fall
Johnny Depp was considered to play Tristan.
Actor who got the part: Brad Pitt
Lemony Snicket's A Series of Unfortunate Events
Johnny Depp was attached to play Count Olaf when Tim Burton was attached to direct. When Burton left, Depp left as well.
Actor who got the part: Jim Carrey
Mars Attacks!
Depp was considered for the role of Jason Stone the reporter.
Actor who got the part: Michael J Fox
The Matrix
According to an interview with Matrix composer Don Davis, Johnny Depp was the Wachowskis' first choice for Neo.
Actor who got the part: Keanu Reeves
Mr. & Mrs. Smith
Depp was considered to play John Smith.
Actor who got the part: Brad Pitt
Platoon
Oliver Stone considered Johnny Depp to play Private Chris Taylor when Depp was young and still unknown.
Actor who got the part: Charlie Sheen
The Rocketeer
Johnny Depp was nearly cast as Cliff Secord.
Actor who got the part: Bill Campbell
Signs
Depp was considered to star as Graham Hess.
Actor who got the part: Mel Gibson
Sin City
Had to pass on the role of Jackie Boy because of prior commitment.
Actor who got the part: Benicio Del Toro
Speed
Reportedly turned down the role of Jack.
Actor who got the part: Keanu Reeves
Superman Returns
Considered for the roles of Lex Luthor and Jor-El.
Actor who got the part: Kevin Spacey, Marlon Brandon
Thelma and Louise
Johhny Depp turned down the role of the hitchhiker.
Actor who got the part: Brad Pitt
The Thin Red Line
Depp was reportedly considered for a role.
Actor who got the part: James Caviezel
Titanic
Was considered for the role of Jack.
Actor who got the part: Leonardo Dicaprio
Titanic
In a phone interview on the Howard Stern show, Johnny Depp would not say which films he has turned down, but Howard Stern reportedly got him to admit that he "labored" through the Titanic script.
Actor who got the part: Leonardo DiCaprio
I'm glad you don't hate jack sparrow....and liz BETTER be unhappy after what she's gona do! that little....(by the by DO NOT think I like liz cause of my siffi cause sailorleo made this for me back when we thought liz/jack was gonna happen and she's made it so nicely that I just CAN'T take it down but...down with liz...)