How would you feel if in the end Marvel...
...tied all the events of Civil War, Planet Hulk, and Annihilation together? If if it did happen, how would you like to see it happen?
I'd certainly be ironic if the US Goverment's exploration of the Negative Zone as a way to contain supervillians (maybe they were already considering it prior to the new place they just built there) in some way contributed to Annihilus invading this universe. I'd be even more ironic if the Hulk returning to Earth with an army was the only thing that kept the Annihilation Wave from destroying Earth.