i didnt think it was that huge a mismatch. spider-man can only with with his webbing, if he spends alot of time dodging and giving reed a huge wokout and when hesgetting exhaused and breathing heavy web his face up, reed can stretch his mouth/nose so it wouldnt be a good tactic to use if you were trying to suffocate him, but the web sticks, and stretches to a degree. it might have more resistance than reed can overcome by simply stretching.
to it depends on how much force reed can put into his stretching. he might be too tired and weak to free himself, especially if he has spider-man trying to web the rest of him up as hes trying to break free. could this possibly work?