Good rule of thumb is if you aren't going to use your computer for the next 6 hours turn if off. leaving it on will ware it down faster, not by much but it will, but turning it on and off every few hours will ware it down much faster so leave it on if your only going to not use it for a few hours.
Also you can program your computer to restart every 24 hours if you leave your computer on all day long like I do.