Ture it's comic writers that would give Batman or Captain America a chance in hell against Spider-Man oh and the fact he hold back meaning Spider-Man. Wolverine is another story since his adamantium laced bones could maybe outlast Spider-Man with his stamina healing factor and unbreakable bones. Then again Spider-Man could wrap something around Wolverines arms and legs that he could physically get out off.
Toad also has that acid and he is suppose to be pretty smart.
Toad- http://www.marveldatabase.com/Toad_%28Mortimer_Toynbee%29