Cyborg Parallax Prime vs 616
Yes, I am smoking crack. Let's just get that out of the way right now.
Henshaw w/super__ prime's genetics (or whatever) available to him, and possessed by the parallax entity, navigates a black hole and ends up in the Marvel U.
Barring interference from an abstract being, will anything stop him from, I dunno...killin' everythang?
Surely there's a really powerful magic user that has what it takes?